| 产品详情 |
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| Product Name | Alpha-Naphthoflavone |
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| Description | Purity >98%. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. Alpha-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 µM). Alpha-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50 s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 µM). Dietary Alpha-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-phenyl-4H-naphtho[1,2-b]pyran-4-one, 7,8-Benzoflavone, NSC 407011 |
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| Gene, Accession, CAS # | CAS: 604-59-1 |
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| Catalog # | LS-H10609 |
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| Order / More Info | Alpha-Naphthoflavone from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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