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| Product Name | Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) protein (His tag) |
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| Description | Ubiquitin-conjugating Enzyme Variant 1a (Uev1a), also known as ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), is a member of the ubiquitin-conjugating (E2) enzyme family. Human Uev1a/UBE2V1 and its mouse ortholog have predicted molecular weights of 19 kDa and 16. 5 kDa, respectively. The human protein shares 89% amino acid (aa) sequence identity with its mouse ortholog. The E2 catalytic core domain of Uev1a/UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm Uev1a/UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked ubiquitin chains and is required for NF-kappaB activation. Uev1a/UBE2V1 is required for UBE2N (Ubc13)/Uev1a Complex-dependent Lys63-linked ubiquitin chain formation. More specifically, Uev1a/UBE2V1 orients the ubiquitin molecule to favor linkage at Lys63 via a non-covalent interaction with the ubiquitin molecule. The human protein contains a non-conserved 30 aa N-terminal tail that functionally differentiates it from Mms2, another E2 enzyme variant and UBE2N/Ubc13 binding partner. Pharmacological inhibition of the UBE2N (Ubc13)/Uev1a complex blocks the proliferation of diffuse large B-cell lymphoma cells, suggesting that this complex may play a role in cancer. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | CIR1|CROC-1|CROC1|UBE2V|UEV-1|UEV1|UEV1A|0610011J09Rik|AI256840|D7Bwg1382e|CROC-1B |
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| Gene, Accession, CAS # | Gene ID: 7335 |
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| Catalog # | ABIN2745987 |
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| Order / More Info | Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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