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| Product Name | Human CXCL11 Protein (Recombinant) |
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| Description | Purity >95% by SDS-PAGE and HPLC, MW: 8.4 kDa (SDS-PAGE). I-TAC (Interferon-inducible T-cell a Chemoattractant), also known as CXCL11, is a chemokine belonging to the CXCL subfamily. Along with Interferon-gamma induced Protein 10 kDa and Monokine Induced by Interferon-gamma , I-TAC is strongly up-regulated by Interferon-gamma and binds to the G-protein coupled receptor CXCR3. The expression of CXCR3 is associated with Th1-mediated immune responses and mediates chemotaxis of Th1 cells. I-TAC induces, maintains, and amplifies the inflammatory reactions, and sustains chronic immune responses against self-antigens. Although CXCR3 was thought to be the exclusive receptor of I-TAC initially, more evidence has shown that I-TAC can also bind to CXCR4 and CXCR7, and that I-TAC plays important roles in tumor development and angiostasis. Recombinant human I-TAC/CXCL11 (rhI-TAC) produced in E. coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhI-TAC has a molecular mass of 8.4 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CXCL11, Beta-R1, Chemokine h174, Chemokine ip-9, Chemokine itac, H174, I-TAC, IP9, ITAC, IP-9, SCYB11, Small inducible cytokine B11, B-R1, C-X-C motif chemokine 11, SCYB9B, Small-inducible cytokine B11 |
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| Gene, Accession, CAS # | CXCL11, Gene ID: 6373 |
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| Catalog # | LS-G27147 |
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| Order / More Info | Human CXCL11 Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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