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| Product Name | IRAK-1/4 Inhibitor |
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| Description | Purity >98%. Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-?B activity, results in the development of some cancers and other diseases, making the development of IRAK inhibitors a potential therapeutic strategy. IRAK-1/4 inhibitor is a benzimidazole that disrupts the activity of IRAK-1 and -4 with IC50 values of 0.3 and 0.2 µM, respectively. It demonstrates IC50 values >10 µM in a panel of 27 other kinases tested. This compound has been used to inhibit a pro-inflammatory response in microglia isolated from clinically diagnosed Alzheimer's disease patients. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro-benzamide |
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| Gene, Accession, CAS # | CAS: 509093-47-4 |
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| Catalog # | LS-H8234 |
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| Order / More Info | IRAK-1/4 Inhibitor from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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