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| Product Name | SR 58611A (hydrochloride) |
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| Description | Purity >98%. SR 58611A is a selective Beta3 -adrenergic receptor agonist (Beta3 -AR; EC50 = 3.5 nM in rat colon). Its activity cannot be blocked by the Beta1 - and Beta2 -AR antagonists CGP 20712A and ICI 118551 , respectively. SR 58611A is minimally active against Beta1 -ARs in rat uterus (EC50 = 499 nM) and inactive against Beta2 -ARs in guinea pig trachea and atrium (EC50 s = >10,000 and >30,000 nM, respectively). SR 58611A activates brown fat metabolism through activation of adenylyl cyclase activity and glycerol release in brown adipocytes (EC50 s = 20 and 11 nM, respectively). It also reduces hypothermia produced by apomorphine and reserpine and potentiates toxicity produced by yohimbine in mice. SR 58611A (0.6 to 2 mg/kg/day) also reduces the number of escape failures in a learned helplessness model of antidepressant-like activity in rats without changes in locomotor activity typically seen with Beta2 -AR agonists. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-acetic acid, ethyl ester, monohydrochloride, Amibegron |
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| Gene, Accession, CAS # | CAS: 121524-09-2 |
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| Catalog # | LS-H10014 |
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| Order / More Info | SR 58611A (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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