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| Product Name | Orlistat |
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| Description | Purity >98%. Orlistat inhibits gastric, pancreatic, and carboxyl ester lipases, preventing the hydrolysis of triglycerides to free fatty acids and monoglycerides, and as such is widely used to treat obesity. With a 120 mg dose before each meal in healthy subjects, orlistat is reported to accelerate gastric emptying and attenuates the secretion of glucose-dependent insulinotropic peptide without affecting plasma responses of cholecystokinin, glucagon-like peptide-1, pancreatic polypeptide, or insulin. 2 It also targets additional serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG. Orlistat potently inhibits human recombinant DAGLAlpha with an IC50 value of 60 nM and at 1 µM inhibits the formation of 2-AG in intact cells in vitro . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-formyl-L-leucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Alli, Tetrahydrolipstatin, Xenical™ |
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| Gene, Accession, CAS # | CAS: 96829-58-2 |
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| Catalog # | LS-H9206 |
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| Price | |
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| Order / More Info | Orlistat from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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