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| Product Name | Heparin-Binding EGF-Like Growth Factor (HBEGF) (Active) protein |
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| Description | Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene.HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87 amino acid gylcoprotein which displays highly regulated gene expression.Ectodomain shedding results in the soluble mature form of HB-EGF which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transmembrane form of HB-EGF is the unique receptor for diptheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces, heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions.Synonyms: Heparin Binding EGF-like growth factor, HBEGF, Diphtheria toxin receptor, DTR |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | hbegf|zgc:165443|HBEGF|zgc:175091|DTR|DTS|DTSF|HEGFL|Dtr|GFHB|Hb-egf|Hegfl|AW047313|Dts|HB-EGF |
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| Gene, Accession, CAS # | Gene ID: 1839 |
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| Catalog # | ABIN2017928 |
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| Order / More Info | Heparin-Binding EGF-Like Growth Factor (HBEGF) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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