| 产品详情 |
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| Product Name | TAK-242 |
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| Description | Purity >98%. Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response. Alternatively, hypoxia or ischemia/reperfusion can trigger signaling through TLR4. TAK-242 is a cell-permeable inhibitor of TLR4 signaling, blocking LPS-induced production of NO, TNF-Alpha, IL-6, and IL-1Beta in macrophages with IC50 values of 1-11 nM. It does not affect signaling through other TLRs. TAK-242 is effective in vivo, suppressing the production of NO, TNF-Alpha, IL-6, and IL-1Beta in mice treated with LPS when given intravenously. Mechanistically, TAK-242 acts by selectively binding TLR4 and preventing its association with adaptor proteins that are essential for signal transduction. TAK-242 is used to study signaling through TLR4 in a variety of pathologies, including sepsis and ischemia/reperfusion injury. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6R-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid, ethyl ester, Resatorvid |
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| Gene, Accession, CAS # | CAS: 243984-11-4 |
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| Catalog # | LS-H10091 |
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| Order / More Info | TAK-242 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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