| 产品详情 |
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| Product Name | Dicoumarol |
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| Description | Purity >98%. Dicoumarol is a competitive inhibitor of NADH:quinone oxidoreductase (NQO1) with IC50 values of 2.6 and 404 nM in the absence and presence of 2 µM BSA, respectively. It has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cells (IC50 s = 52 and 19 µM, respectively, after a 96 hour incubation). Dicoumarol inhibits stress-activated protein kinase (SAPK) in HEK293 cells (IC50 = 19-33 µM) at a point upstream of MEKK1 and downstream of TNF receptor-associated factor 2 (TRAF2), and it inhibits TNF-Alpha and LPS-induced NF-?B activation in HeLa cells. It also has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 µM) by suppressing JNK activation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3,3'-methylenebis[4-hydroxy-2H-1-benzopyran-2-one, NSC 17860, NSC 221570, NSC 41834 |
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| Gene, Accession, CAS # | CAS: 66-76-2 |
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| Catalog # | LS-H7440 |
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| Price | |
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| Order / More Info | Dicoumarol from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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