| 产品详情 |
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| Product Name | Recombinant Human Muscleblind-like protein 1 (MBNL1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 57kDa. Full Length of Isoform 5: 1-382aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the st-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assbly. Binds to the 5'-YGCU (U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Triplet-expansion RNA-binding protein |
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| Gene, Accession, CAS # | MBNL1, UniProt: Q9NR56 |
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| Catalog # | RPC23724 |
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| Order / More Info | Recombinant Human Muscleblind-like protein 1 (MBNL1) from BIOMATIK |
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| Product Specific References | n/a |
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