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| Product Name | 3-Nitropropionic Acid |
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| Description | Purity >95%. 3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain. This compound is a natural toxin of certain plants and fungi. Administration of 3-NP to rats (12 mg/kg per day) produces progressive striatal degeneration, while lower doses (8 mg/kg daily) in nonhuman primates results in neuropathologic and clinical features of Huntington's disease. Conversely, Huntington's disease results in a loss of Complex II activity. 3-NP also induces convulsions and is used to examine interventions effective in a mouse model of epilepsy. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-nitro-propanoic acid, 3-NP, NSC 64266, -Beta-Nitropropionic Acid |
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| Gene, Accession, CAS # | CAS: 504-88-1 |
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| Catalog # | LS-H6073 |
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| Order / More Info | 3-Nitropropionic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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