| 产品详情 |
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| Product Name | FTase Inhibitor II |
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| Description | Purity >80%. Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins. This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function at, membranes. FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras. It does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM). FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine, Farnesyltransferase Inhibitor II, FTI-II |
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| Gene, Accession, CAS # | CAS: 156707-43-6 |
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| Catalog # | LS-H7851 |
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| Price | |
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| Order / More Info | FTase Inhibitor II from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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