| 产品详情 |
| Edit |   |
|---|
| Product Name | Kifunensine |
|---|
| Description | Purity >98%. Kifunensine was originally isolated from the actinomycete Kitasatosporia kifunensine No. 9482 and shown to be a weak inhibitor of aryl mannosidase. It has since been shown to be a potent and selective inhibitor of class I Alpha-mannosidases and may serve as a key inhibitor of glycoprotein biosynthesis. Kifunensine inhibits both human endoplasmic reticulum Alpha-1,2-mannosidase I and members of the Golgi subfamily of the class I mannosidases (Golgi Alpha-mannosidase IA, IB, and IC) exhibiting Ki values of 130 and 23 nM, respectively. It also inhibits mung bean Alpha-1,2-mannosidase I with an IC50 value of 20-50 nM. Kifunensine can be used to block Alpha-mannosidase I activity at the endoplasmic reticulum (ER), preventing the removal of desired mutated proteins through ER quality control mechanisms. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione, FR900494 |
|---|
| Gene, Accession, CAS # | CAS: 109944-15-2 |
|---|
| Catalog # | LS-H8346 |
|---|
| Price | |
|---|
| Order / More Info | Kifunensine from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|