| 产品详情 |
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| Product Name | OTX015 |
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| Description | Purity >95%. The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50 s = 10-19 nM). It displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias, downregulating c-Myc expression and inducing cell cycle arrest and apoptosis. At 100 mg/kg, OTX015 has been shown to inhibit the growth of Ty82 BRD-NUT midline carcinoma tumors in nude mice by 79%. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (6S)-4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, HY-15743, (-)-OTX015 |
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| Gene, Accession, CAS # | CAS: 202590-98-5 |
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| Catalog # | LS-H9215 |
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| Order / More Info | OTX015 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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