| 产品详情 |
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| Product Name | Trelagliptin |
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| Description | Purity >98%. Dipeptidyl peptidase 4 (DPP-4) is an intrinsic membrane glycoprotein that acts as an exopeptidase, cleaving oligopeptides after the second amino acid from the N-terminal end. One of its substrates is glucagon-like peptide 1, an incretin that stimulates insulin biosynthesis and secretion while inhibiting glucagon release in a glucose-dependent manner. Trelagliptin is a pyrimidinedione-based, long-acting inhibitor of DPP-4 (IC50 = 4 nM). It demonstrates >10,000-fold selectivity over other peptidases. Trelagliptin has been used to improve glucose tolerance and postprandial plasma insulin levels in Zucker fa/fa rats. In 2014 this compound underwent phase III clinical trials. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-benzonitrile, SYR-472 |
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| Gene, Accession, CAS # | CAS: 865759-25-7 |
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| Catalog # | LS-H10291 |
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| Order / More Info | Trelagliptin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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