| 产品详情 |
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| Product Name | HC-030031 |
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| Description | Purity >98%. Transient receptor potential cation channel A1 (TRPA1) is an ankyrin-like ion channel which acts as a sensor for chemical irritants, pain, and cold. It is activated by allyl isothiocyanate (AITC), formalin, hydrogen peroxide, tear gas, and other compounds. HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 s = 6.2 and 5.3 µM, respectively). It does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or NaV 1.2 channels. HC-030031 can be used in cells or delivered to animals orally, by inhalation, or by injection. Oral administration (100 mg/kg) of HC-030031 significantly reversed mechanical hypersensitivity in rat models of chronic inflammatory or neuropathic pain, while local injection (100 µg) into inflamed mouse hind paws attenuated mechanical, but not heat, hypersensitivity. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide |
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| Gene, Accession, CAS # | CAS: 349085-38-7 |
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| Catalog # | LS-H8077 |
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| Order / More Info | HC-030031 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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