| 产品详情 |
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| Product Name | HC-067047 |
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| Description | Purity >98% by NMR, TLC. HC-067047 is a potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4a-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels. Increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis. Inhibits brain edema in middle cerebral artery occlusion mice. HC-067047 induces an increase in core body temperature accompanied by increased oxygen consumption in Wistar rats. Active in vivo. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide |
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| Gene, Accession, CAS # | CAS: 883031-03-6 |
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| Catalog # | LS-H14705 |
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| Order / More Info | HC-067047 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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