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| Product Name | Ambroxol |
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| Description | Purity >98%. Ambroxol is a secretolytic compound. It decreases short-circuit current ex vivo in canine tracheal epithelium (IC50 = 39.4 nM) when applied submucosally, which leads to decreased water absorption and mucosal viscosity, an effect that can be blocked by pretreatment with the sodium channel blocker amiloride . Ambroxol (10 mg/kg per day) stimulates release of pulmonary surfactant (mucus), mucus protease inhibitor, IgG, and IgA as well as decreases viral survival and release of the cytokines TNF-Alpha, IL-12, and interferon Gamma (IFN-Gamma) in the airway of a mouse model of H3N2 influenza infection. It blocks tetrodotoxin-resistant sodium channels (Nav 1.8) in vitro, and reduces flinching in a rat formalin paw model of pain and mechanical allodynia in a rat model of partial nerve ligation when administered at doses ranging from 100-1,000 mg/kg. Ambroxol (1-5 mM in drinking water) increases glucocerebrosidase activity in the brainstem, midbrain, cortex, and striatum of wild-type, glucocerebrosidase mutant, and human Alpha-synuclein overexpressing mice. It also reduces total and phosphorylated Alpha-synuclein in mice overexpressing human Alpha-synuclein. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | trans -4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol, NA 872 |
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| Gene, Accession, CAS # | CAS: 18683-91-5 |
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| Catalog # | LS-H6497 |
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| Order / More Info | Ambroxol from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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