| 产品详情 |
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| Product Name | HCV-NS3-S1a protein |
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| Description | HCV-NS3-S1a (residues 1359-1456) protein.The protein contains the HCV NS3 (c33c) immunodominant region, amino acids 1359-1456.Hepatitis C NS3 protein is purified by proprietarychromatographic techniques.The nonstructural protein NS3 of the hepatitis C virus(HCV) is indispensable for virus replication and a multifunctional enzyme that contains three catalytic activitiessuch as serine protease, helicase, and NTPase. TheN-terminal domain of the protein contains proteaseactivity and the C-terminal domain contains nucleotidetriphosphatase and RNA helicase activity.It has been shown that NS2/3 cleavage is mediatedby NS2-3 protease, whereas NS3 serine protease isresponsible for the other four cleavage sites of thenonstructural (NS) region.Immunoblot analysis on serum samples from 90 patientswith chronic hepatitis C virus infection revealed fourputative immunogenic regions within the NS3 proteinof the virus: E (around amino acids 1250/1251), A(within amino acids 1250-1334), A/B (around aminoacids 1323 and 1334), and B/C (around amino acids1407 and 1412). Among them, region E was mostimmunodominant, and region A was recognized muchless frequently by patients with cirrhosis than by thosewith chronic hepatitis. Purity >95% by SDS-PAGE |
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| Size | 1 mg, 100 ug |
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| Concentration | n/a |
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| Applications | ELISA, WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | orb97920 |
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| Order / More Info | HCV-NS3-S1a protein from BIORBYT LTD. |
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| Product Specific References | n/a |
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