| 产品详情 |
| Edit |   |
|---|
| Product Name | HCV-NS3-S5a protein |
|---|
| Description | HCV-NS3-S5a (residues 1192-1459) protein.The protein contains the full-length HCV NS3 (c33c)immunodominant region, amino acids 1192-1459.Hepatitis C NS3 protein is purified by proprietarychromatographic techniques.The nonstructural protein NS3 of the hepatitis C virus(HCV) is indispensable for virus replication and a multifunctional enzyme that contains three catalytic activitiessuch as serine protease, helicase, and NTPase. TheN-terminal domain of the protein contains proteaseactivity and the C-terminal domain contains nucleotidetriphosphatase and RNA helicase activity.It has been shown that NS2/3 cleavage is mediatedby NS2-3 protease, whereas NS3 serine protease isresponsible for the other four cleavage sites of thenonstructural (NS) region.Immunoblot analysis on serum samples from 90 patientswith chronic hepatitis C virus infection revealed fourputative immunogenic regions within the NS3 proteinof the virus: E (around amino acids 1250/1251), A(within amino acids 1250-1334), A/B (around aminoacids 1323 and 1334), and B/C (around amino acids1407 and 1412). Among them, region E was mostimmunodominant, and region A was recognized muchless frequently by patients with cirrhosis than by thosewith chronic hepatitis. Purity >95% by SDS-PAGE and RP-HPLC. |
|---|
| Size | 100 ug |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA, WB |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | orb97919 |
|---|
| Price | |
|---|
| Order / More Info | HCV-NS3-S5a protein from BIORBYT LTD. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|