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| Product Name | Recombinant Mouse Suppressor of cytokine signaling 1 (Socs1) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 28.7kDa. Full Length: 1-212aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Mus musculus (Mouse). SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | JAK-binding protein |
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| Gene, Accession, CAS # | Socs1, UniProt: O35716 |
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| Catalog # | RPC22035 |
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| Order / More Info | Recombinant Mouse Suppressor of cytokine signaling 1 (Socs1) from BIOMATIK |
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| Product Specific References | n/a |
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