| 产品详情 |
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| Product Name | CYM 50308 |
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| Description | Purity >97%. Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P4 couples to G alpha i, G alpha o, and G alpha 12/13 proteins leading to the stimulation of MAPK/ERK signaling pathways, as well as to PLC and Rho-Cdc42 activation, and is thought to contribute to immune responses. CYM 50308 is a novel agonist of SIP4 (EC50 = 56 nM) that displays 37-fold selectivity against S1P5 (EC50 = 2.1 µM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2Z,5Z)-5-[[1-(2,4-difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-4-thiazolidinone, CID-49835928, ML-248 |
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| Gene, Accession, CAS # | CAS: 1345858-76-5 |
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| Catalog # | LS-H104 |
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| Price | |
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| Order / More Info | CYM 50308 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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