| 产品详情 |
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| Product Name | CYM 5442 |
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| Description | Purity >95%. Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors, S1P1 /EDG-1, S1P2 /EDG-5, S1P3 /EDG-3, S1P4 /EDG-6, and S1P5 /EDG-8. S1P1 is important for vascular development and lymphocyte maturation, migration, and trafficking. CYM 5442 is a full agonist for S1P1 internalization, phosphorylation, and ubiquitination (EC50 = 1.35 nM). It is ineffective at S1P2, S1P3, S1P4, and S1P5 at concentrations up to 10 µM. CYM 5442 has been found to activate S1P1 -mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 with an EC50 value of 46 nM. At 50 nM, CYM 5442 can induce S1P1 -dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[4-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]amino]-ethanol |
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| Gene, Accession, CAS # | CAS: 1094042-01-9 |
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| Catalog # | LS-H7310 |
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| Order / More Info | CYM 5442 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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