| 产品详情 |
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| Product Name | INCB024360 analog |
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| Description | Purity >98%. Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. It has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. INCB024360 analog is a potent IDO1 inhibitor that demonstrates IC50 values of 67 and 19 nM for human IDO in enzymatic activity and HeLa cell assays, respectively. It is inactive against tryptophan 2,3-dioxygenase (IC50 > 10 µM). At 25-75 mg/kg, subcutaneous administration of INCB024360 analog to mice significantly decreased kynurenine levels in plasma and dose-dependently reduced the growth of GM-CSF-secreting B16 tumor xenografts. A fluorine-18 moiety has been used to label this compound for use as a probe for imaging IDO1 expression via positron emission tomography. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide, IDO5L |
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| Gene, Accession, CAS # | CAS: 914471-09-3 |
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| Catalog # | LS-H8198 |
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| Order / More Info | INCB024360 analog from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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