| 产品详情 |
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| Product Name | BIX02189 |
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| Description | Purity >98%. MEK5, also known as MAP2K5, phosphorylates ERK5 (MAPK7) in signaling pathways involved in stress-induced apoptosis, neuronal survival, cardiac development, and angiogenesis. BIX02189 is a potent inhibitor of both MEK5 and ERK5 (IC50 s = 1.5 and 59 nM, respectively), preventing transcriptional activation of the downstream target MEF2C. It minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2. BIX02189 blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation of ERK1/2, in HeLa cells. It has been used to investigate the roles of MEK5/ERK5 signaling in nerve growth factor-mediated neurite outgrowth and myeloid cell differentiation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide |
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| Gene, Accession, CAS # | CAS: 1265916-41-3 |
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| Catalog # | LS-H6840 |
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| Price | |
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| Order / More Info | BIX02189 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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