| 产品详情 |
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| Product Name | PF-CBP1 |
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| Description | Purity >98%. CREB-binding protein (CBP) and E1A-associated protein p300 are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development. Both CBP and p300 contain bromodomains, which mediate their binding to acetylated lysine residues on histones and other proteins. PF-CBP1 is an inhibitor of the CBP and p300 bromodomains (IC50 s = 125 and 363 nM, respectively). It displays greater than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins. PF-CBP1 reduces the expression of inflammatory cytokines by LPS-stimulated primary macrophages. It also suppresses the expression of RGS4 (regulator of G protein signaling 4) in primary cortical neurons. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H9357 |
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| Price | |
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| Order / More Info | PF-CBP1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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