| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | RAP1A, Member of RAS Oncogene Family (RAP1A) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse, rat, human |
|---|
| Isotype | n/a |
|---|
| Format | affinity purified |
|---|
| Size | 50 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Rap1 and Rap2 belong to the Ras subfamily of small GTPases and are activated by a wide variety of stimuli through integrins, receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCR), death domain associated receptors (DD-R) and ion channels . Like other small GTPases, Rap activity is stimulated by guanine nucleotide exchange factors (GEF) and inactivated by GTPase activating proteins (GAP). A wide variety of Rap GEFs have been identified: C3G connects Rap1 with RTKs through adaptor proteins such as Crk, Epacs (or cAMP-GEFs) transmit signals from cAMP, and CD-GEFs (or CalDAG-GEFs) convey signals from either or both Ca2+ and DAG . Rap1 primarily regulates multiple integrin-dependent processes such as morphogenesis, cell-cell adhesion, hematopoiesis, leukocyte migration and tumor invasion . Rap1 may also regulate proliferation, differentiation and survival through downstream effectors including B-Raf, PI3K, RalGEF and phospholipases (PLCs) . Rap1 and Rap2 are not fuctionally redundant as they perform overlapping but distinct functions . Recent research indicates that Rap2 regulates Dsh subcellular localization and is required for Wnt signaling in early development . Synonyms: RAP1A,KREV-1,KREV1,RAP1,SMGP21 , |
|---|
| Immunogen | Recombinant protein of human RAP1A |
|---|
| Other Names | wu:fc66g06|zgc:86676|krev-1|krev1|rap1|KREV-1|KREV1|RAP1|SMGP21|RAP-1A|rap 1A|AI848598|G-22K|Krev-1|Rap1 |
|---|
| Gene, Accession # | Gene ID: 5906,109905,295347 |
|---|
| Catalog # | ABIN1683935 |
|---|
| Price | |
|---|
| Order / More Info | RAP1A, Member of RAS Oncogene Family (RAP1A) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|