| 产品详情 |
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| Product Name | AT7519 (hydrochloride) |
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| Description | Purity >98%. AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3Beta (IC50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50 s = 40-940 nM in vitro ), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3Beta by down-regulating GSK3Beta phosphorylation, which contributes to AT7519-induced apoptosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide, monohydrochloride |
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| Gene, Accession, CAS # | CAS: 902135-91-5 |
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| Catalog # | LS-H6650 |
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| Price | |
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| Order / More Info | AT7519 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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