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| Product Name | Chemokine (C-X-C Motif) Ligand 11 (CXCL11) (AA 22-94) (Active) protein |
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| Description | I-TAC (Interferon-inducible T-cell alpha Chemoattractant), also known as CXCL11, is a chemokine belonging to the CXCL subfamily. Along with Interferon-gamma induced Protein 10 kDa and Monokine Induced by Interferon-gamma, I-TAC is strongly up-regulated by Interferon-gamma and binds to the G-protein coupled receptor CXCR3. The expression of CXCR3 is associated with Th1-mediated immune responses and mediates chemotaxis of Th1 cells. I-TAC induces, maintains, and amplifies the inflammatory reactions, and sustains chronic immune responses against self-antigens. Although CXCR3 was thought to be the exclusive receptor of I-TAC initially, more evidence has shown that I-TAC can also bind to CXCR4 and CXCR7, and that I-TAC plays important roles in tumor development and angiostasis. Recombinant human I-TAC/CXCL11 (rhI-TAC) produced in E. coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhI-TAC has a molecular mass of 8.4 kDa analyzed by reducing SDS-PAGE. Synonyms: |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | H174|I-TAC|IP-9|IP9|SCYB11|SCYB9B|b-R1|Cxc11|I-tac|Ip9|Itac|Scyb11|Scyb9b|betaR1 |
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| Gene, Accession, CAS # | Gene ID: 6373 |
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| Catalog # | ABIN2017968 |
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| Order / More Info | Chemokine (C-X-C Motif) Ligand 11 (CXCL11) (AA 22-94) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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