| 产品详情 |
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| Product Name | 2-Acetylphenothiazine |
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| Description | Purity >98%. 2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 µM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(10H-phenothiazin-2-yl)-ethanone, 2-APT, ML-171, NSC 169669, NSC 57951 |
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| Gene, Accession, CAS # | CAS: 6631-94-3 |
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| Catalog # | LS-H5963 |
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| Price | |
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| Order / More Info | 2-Acetylphenothiazine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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