| 产品详情 |
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| Product Name | SMAD Family Member 4 (SMAD4) (AA 1-552) protein (His tag) |
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| Description | SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumor suppressor. It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.Alternative Names: Mothers Against Decapentaplegic Homolog 4, MAD Homolog 4, Mothers Against DPP Homolog 4, Deletion Target in Pancreatic Carcinoma 4, SMAD Family Member 4, SMAD 4, Smad4, hSMAD4, SMAD4, DPC4, MADH4 |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | smad4|DPC4|JIP|MADH4|MYHRS|AW743858|D18Wsu70e|Madh4|XSmad4alpha|Xsmad4|dpc4|jip|madh4|xsmad4a |
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| Gene, Accession, CAS # | Gene ID: 4089 |
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| Catalog # | ABIN1692097 |
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| Order / More Info | SMAD Family Member 4 (SMAD4) (AA 1-552) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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