| 产品详情 |
| Edit |   |
|---|
| Product Name | SMAD Family Member 4 (SMAD4) (AA 1-552) protein (His tag) |
|---|
| Description | SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumor suppressor. It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.Alternative Names: Mothers Against Decapentaplegic Homolog 4, MAD Homolog 4, Mothers Against DPP Homolog 4, Deletion Target in Pancreatic Carcinoma 4, SMAD Family Member 4, SMAD 4, Smad4, hSMAD4, SMAD4, DPC4, MADH4 |
|---|
| Size | 1 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | smad4|DPC4|JIP|MADH4|MYHRS|AW743858|D18Wsu70e|Madh4|XSmad4alpha|Xsmad4|dpc4|jip|madh4|xsmad4a |
|---|
| Gene, Accession, CAS # | Gene ID: 4089 |
|---|
| Catalog # | ABIN1692095 |
|---|
| Price | |
|---|
| Order / More Info | SMAD Family Member 4 (SMAD4) (AA 1-552) protein (His tag) from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|