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| Product Name | Interleukin 21 (IL21) (Active) protein |
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| Description | IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naA?ve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (gamma,c) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Synonym: Interleukin-21 (IL-21), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4. |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL-21|Za11 |
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| Gene, Accession, CAS # | Gene ID: 59067 |
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| Catalog # | ABIN988059 |
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| Order / More Info | Interleukin 21 (IL21) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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