| 产品详情 |
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| Product Name | Leptomycin B |
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| Description | Purity >99% by HPLC. A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence . At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF- Kappa B/I Kappa B, and it stabilizes the expression of p53. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ATS 1287B, CI-940, CL-1957A, PD-114720, Elactocin, LMB, Mantuamycin |
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| Gene, Accession, CAS # | CAS: 87081-35-4 |
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| Catalog # | LS-H2485 |
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| Order / More Info | Leptomycin B from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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