| 产品详情 |
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| Antigenic Specificity | PDK1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 5-10 µg/mg lysate, Western Blot: 1:2,000-1:10,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PDK1 Polyclonal Antibody. PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research. |
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| Immunogen | n/a |
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| Other Names | 3-phosphoinositide dependent protein kinase-1, hPDK1; PDK1 |
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| Gene, Accession # | Entrez: 18607, 5170; Uniprot: O15530, Q9Z2A0 |
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| Catalog # | A302-130A |
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| Price | |
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| Order / More Info | PDK1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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