| 产品详情 |
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| Product Name | Rilmenidine (hemifumarate) |
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| Description | Purity >98%. Rilmenidine is a centrally acting antihypertensive agent that has been shown to lower arterial pressure in various animal models by inhibiting the tonic activity of sympathoexcitatory neurons in the rostral ventrolateral medulla. Rilmenidine targets the nonadrenergic imidazoline-binding site I1 receptor with a Ki value of 7.1 nM and demonstrates weaker affinity for the I2 receptor with a Ki value of 5.2 µM. It can also act as an agonist of Alpha2 -adrenergic receptors, but demonstrates ~30-fold greater selectivity for I1 receptors compared to Alpha2 -adrenergic receptors. Rilmenidine is reported to induce autophagy as evidenced by a ~350% increase in LC3-II levels in PC12 cells when treated with 1 µM of the I1 agonist. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine, 2E-butenedioate (2:1), Oxaminozoline, S 3341 |
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| Gene, Accession, CAS # | CAS: 207572-68-7 |
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| Catalog # | LS-H9723 |
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| Order / More Info | Rilmenidine (hemifumarate) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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