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| Product Name | 17Beta-hydroxy Wortmannin |
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| Description | Purity >98%. 17Beta-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17Beta-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 µM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 17Beta-hydroxy-11-(acetyloxy)-1S,6bR,7,8,9aS,10,11R,11bR-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione |
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| Gene, Accession, CAS # | CAS: 58053-83-1 |
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| Catalog # | LS-H5869 |
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| Order / More Info | 17Beta-hydroxy Wortmannin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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