| 产品详情 |
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| Product Name | Recombinant Human Caspase-14 (CASP14) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 37.2kDa. Full Length of Mature Protein: 153-240aa. N-terminal GST-tagged. Homo sapiens (Human). Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Ses to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function. Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | CASP14, UniProt: P31944 |
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| Catalog # | RPC21029 |
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| Order / More Info | Recombinant Human Caspase-14 (CASP14) from BIOMATIK |
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| Product Specific References | n/a |
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