| 产品详情 |
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| Product Name | (S)-10-hydroxy-Camptothecin |
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| Description | Purity >98%. DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata . It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 µM). In vitro treatment of human HepG2 cells with 5-20 µM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2 /M phase. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, ChEMBL 273862, NSC 107124 |
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| Gene, Accession, CAS # | CAS: 19685-09-7 |
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| Catalog # | LS-H5669 |
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| Order / More Info | (S)-10-hydroxy-Camptothecin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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