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| Product Name | MK-886 (sodium salt) |
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| Description | Purity >99%. Arachidonic acid and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO). The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active. MK-886 binds to FLAP with high-affinity and prevents 5-LO activation. MK-886 inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM. In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid, sodium salt |
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| Gene, Accession, CAS # | CAS: 118427-55-7 |
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| Catalog # | LS-H8719 |
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| Price | |
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| Order / More Info | MK-886 (sodium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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