| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human Sorting nexin-1 (SNX1) |
|---|
| Description | Purity > 90% as determined by SDS-PAGE. MW: 75.1kDa. Full Length: 1-522aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Involved in several stages of intracellular trafficking. Interacts with mbranes containing phosphatidylinositol 3-phosphate (PtdIns (3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns (3,5)P2). Acts in part as component of the retromer mbrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma mbrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor mbrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense mbrane curvature and has in vitro vesicle-to-mbrane rodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvent in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent mbrane rodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking. |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | SNX1, UniProt: Q13596 |
|---|
| Catalog # | RPC23049 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human Sorting nexin-1 (SNX1) from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|