| Edit |   |
|---|
| Antigenic Specificity | Osteopontin |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 400 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry: 1:10-1:50, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Osteopontin Polyclonal Antibody. Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D. |
|---|
| Immunogen | n/a |
|---|
| Other Names | Osteopontin; Bone sialoprotein 1; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Nephropontin; Uropontin; OPN; BNSP; SPP1 |
|---|
| Gene, Accession # | Entrez: 6696; Uniprot: P10451 |
|---|
| Catalog # | PA5-13494 |
|---|
| Price | |
|---|
| Order / More Info | Osteopontin Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|