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| Product Name | Recombinant Human Histone-lysine N-methyltransferase SETD7 (SETD7), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 48.7kDa. Partial: 110--366aa. N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Histone H3-K4 methyltransferase SETD7 |
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| Gene, Accession, CAS # | SETD7, UniProt: Q8WTS6 |
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| Catalog # | RPC23391 |
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| Order / More Info | Recombinant Human Histone-lysine N-methyltransferase SETD7 (SETD7), partial from BIOMATIK |
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| Product Specific References | n/a |
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