| 产品详情 |
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| Product Name | IHR-1 |
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| Description | Purity >98% by NMR. Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Inhibitor of Hedgehog Response 1, N,N'-1,4-Phenylene bis[2,5-dichloro-benzamide |
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| Gene, Accession, CAS # | CAS: 548779-60-8 |
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| Catalog # | LS-H626 |
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| Order / More Info | IHR-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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