| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) (aa 665-680), (Middle Region) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, rat |
|---|
| Isotype | n/a |
|---|
| Format | immunogen affinity purified |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | SERCA1(SARCOPLASMIC RETICULUM Ca(2+)-ATPase 1), also called ATP2A1, is an enzyme that in humans is encoded by the ATP2A1 gene. This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. The SERCA1 gene is mapped on 16p11.2. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Zhang et al.(1995)determined that the human ATP2A1 gene is 26 kb long and contains 23 exons, 1 of which can be alternatively spliced.Overexpression of S1T, but not full-length SERCA1, induced ER stress in HeLa cells and amplified ER stress through the PERK(EIF2AK3)-EIF2A -ATF4 -CHOP(DDIT3) pathway. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. |
|---|
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human SERCA1 ATPase(665-680aa EQREACRRACCFARVE), identical to the related rat and mouse sequences. |
|---|
| Other Names | cb279|serca|serca1|wu:cegs655|wu:fb17h11|wu:fb19b10|zgc:92110|ATP2A1|atp2a|atp2a2|atp2b|ca-p60a|dar|serca2|SERCA1|ATP2A3|SERCA1a|Serca1|ATP2A |
|---|
| Gene, Accession # | Gene ID: 487,116601 |
|---|
| Catalog # | ABIN1673198 |
|---|
| Price | |
|---|
| Order / More Info | ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1) (aa 665-680), (Middle Region) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 2943216, 2936465, 8825625 |
|---|
| 产品资料 |
|
|