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| Product Name | Recombinant Naja kaouthia Alpha-cobratoxin |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 37.8kDa. Full Length: 1-71aa. N-terminal 10xHis-GST-tagged and C-terminal Myc-tagged. Naja kaouthia (Monocled cobra) (Naja siamensis). Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta (CHRNA1/CHRNB1/CHRNG/CHRND) nAChR) (IC50=4.5 nM on Torpedo californica membranes) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (IC50=105 nM).2 Publications Homodimer: binds with high affinity (but lower than the monomeric form) to muscular (IC50=9.7 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (IC50=1370 nM).However, it acquires (compared to the monomeric form) the capacity to block alpha-3/beta-2 (CHRNA3/CHRNB2) nAChRs Heterodimer with cytotoxin 3 (AC P01446): is slightly more active than the homodimer in inhibiting alpha-7 nAChR and is considerably more active in blocking the alpha-3-beta-2 nAChR. The monomeric form has no effect on alpha-3/beta-2 (CHRNA3/CHRNB2) nAChR. It does not show any blockade of the nicotine-evoked release of dopamine and does not affect ACh release. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Alpha-elapitoxin-Nk2a; Short name:Alpha-EPTX-Nk2a; Long neurotoxin 1; Siamensis 3 |
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| Gene, Accession, CAS # | UniProt: P01391 |
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| Catalog # | RPC22809 |
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| Order / More Info | Recombinant Naja kaouthia Alpha-cobratoxin from BIOMATIK |
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| Product Specific References | n/a |
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