| 产品详情 |
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| Product Name | Recombinant Human Trimethylguanosine synthase (TGS1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 31.6kDa. Partial: 713-853aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m (2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | CLL-associated antigen KW-2; Cap-specific guanine-N2 methyltransferaseHepatocellular carcinoma-associated antigen 137Nuclear receptor coactivator 6-interacting protein; PRIP-interacting protein with methyltransferase motif; PIMT; PIPMT |
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| Gene, Accession, CAS # | TGS1, UniProt: Q96RS0 |
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| Catalog # | RPC23438 |
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| Price | |
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| Order / More Info | Recombinant Human Trimethylguanosine synthase (TGS1), partial from BIOMATIK |
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| Product Specific References | n/a |
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