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| Product Name | Recombinant Mouse Eotaxin protein (Ccl11) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 44.65kDa. Full Length of Mature Protein: 22-401aa. C-terminal 6xHis-tagged. Homo sapiens (Human). TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-?B) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM)) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo. TNFRSF11B binding to RANKL on osteoblast/stromal cells, blocks the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG |
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| Gene, Accession, CAS # | TNFRSF11B, UniProt: O00300 |
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| Catalog # | RPC26941 |
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| Order / More Info | Recombinant Mouse Eotaxin protein (Ccl11) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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