| 产品详情 |
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| Product Name | AH 23848 (calcium salt) |
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| Description | Purity >90%. Thromboxane (TXA2 ) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2 ) activates four E prostanoid (EP) receptors, EP1-4 . AH-23848 is a dual antagonist of TP1 and EP4 receptors. It originally was found to inhibit TXA2 -induced platelet aggregation (IC50 = 0.26 µM)1 and the contraction of human bronchial smooth muscle induced by the TP agonist U-46619. AH-23848 was subsequently demonstrated to impair PGE2 -mediated relaxation of piglet saphenous vein by antagonizing the PGE2 receptor EP4 . By inhibiting EP4, it likewise suppresses serum-induced cAMP generation, cyclin A synthesis, and the proliferation of fibroblasts4, as well as reduces metastasis in a mouse model of metastatic breast cancer. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (4Z)-rel -7-[(1R,2R,5S)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-4-heptenoic acid, hemicalcium salt |
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| Gene, Accession, CAS # | CAS: 81496-19-7 |
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| Catalog # | LS-H6454 |
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| Price | |
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| Order / More Info | AH 23848 (calcium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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