| 产品详情 |
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| Product Name | Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 39.4kDa. Full Length: 1-313aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Bos taurus (Bovine). Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator |
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| Gene, Accession, CAS # | PRKRA, UniProt: Q2HJ92 |
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| Catalog # | RPC23078 |
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| Order / More Info | Recombinant Bovine Interferon-inducible double stranded RNA-dependent protein kinase activator A (PRKRA) from BIOMATIK |
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| Product Specific References | n/a |
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